"Death matters: You just get one save file, meaning you can’t take back any deaths you experience, and in Sekiro, each death has real consequences. In addition to the loss of half your money and skill points, accumulating deaths eventually causes Dragonrot, a sickness that afflicts computer-controlled characters you interact with in real-time. They’ll cough when you interact with them, and it seems like certain dialogue options disappear. Having a Dragonrot indicator in your inventory means that upon dying again, you have less of a chance of receiving Unseen Aid, a base one-in-three chance of not losing gold and skill points. Additionally, any non-boss enemies you kill respawn and you’re sent back to the last Sculptor’s Idol (the game’s resting points) you used.
Players are afforded a resurrection ability early on, and it’s up to them whether to choose to use it as a second wind toward the culmination of, say, a tough boss fight, or a signal to turn tail and get the hell out of dodge while they still can to regroup.."